U.S. Department of Energy Launches Genesis Mission with 278 AI-Powered Scientific Research Projects

Summary

The U.S. Department of Energy has announced the first 278 projects selected under its Genesis Mission Request for Applications (RFA), a historic government initiative designed to accelerate scientific breakthroughs through AI-enabled research workflows. The record-breaking funding opportunity generated the largest response in DOE history, with projects spanning all 50 states and involving 342 participating institutions including national laboratories, universities, companies, and nonprofit organizations. These projects will focus on critical challenges in energy, discovery science, and national security, with the largest single investment being a $60 million, three-year nuclear energy project that will use AI to deliver safer, faster nuclear facilities at reduced operating costs.

The Genesis Mission is part of President Trump's broader initiative to double America's scientific productivity by combining DOE's scientific capabilities with advanced AI, high-performance computing, and the nation's leading researchers. The selected awards include 87 projects led by DOE and NNSA National Laboratories, 168 led by universities, 19 led by companies, and 4 led by nonprofit organizations. Awardees will gain access to the Genesis Mission Platform, which includes AI agent frameworks, advanced AI models, software from industry partners, and high-performance computing resources across DOE's National Laboratories.

• Genesis Mission aims to double America's scientific productivity by integrating AI, high-performance computing, and leading researchers across energy, discovery science, and national security